Mesalazine vanishing time from rectal mucosa following its topical administration

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Mesalazine vanishing time from rectal mucosa following its topical administration.

To investigate how long and how much Mesalazine (M) is available inside the rectal mucosa following its topical instillation, in patients (pts) with Ulcerative Colitis (UC). Two rectal biopsies for M concentration were obtained from 45 UC pts in clinical remission and on oral M treatment (OT), before a 4g enema randomly given to consentient pts every day (Group A, 15 pts), every 2 days (Group B...

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ژورنال

عنوان ژورنال: Journal of Crohn's and Colitis

سال: 2010

ISSN: 1873-9946

DOI: 10.1016/j.crohns.2009.08.003